Targeting kynurenine metabolism in aging and age-associated disease George Sutphin, PhD Assistant Professor Molecular & Cellular Biology BIO5 Institute University of Arizona Why Attend this Seminar? Tryptophan is an essential amino acid that our cells use to build proteins and produce neurotransmitters and other bioactive metabolites. The majority of ingested tryptophan is metabolized through the kynurenine pathway. This seminar will discuss recent evidence that inhibiting enzymes or supplementing metabolites in the kynurenine pathway can extend healthy lifespan and improve age-associated pathology in both the roundworm Caenorhabditis elegans and mice. We will focus specifically on the benefits of the kynurenine metabolite 3-hydroxyanthranilic acid for extending healthy lifespan and promoting pathogen resistance during aging. Meeting ID: 930 4620 8772
Passcode: PATH520
Sign-In & Evaluation Form Online: https://forms.gle/dfmHNTVdxH9Dbwbt9 Sign-in is required for students registered in PATH 520. All other attendees are encouraged to track attendance and complete an evaluation of the presentation. |